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copA [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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copA [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

copper-transporting ATPase, resistance to copper
locus
BSU33500
pI
5.00
mw
85.00 kDa
function
copper export, detoxification
product
copper transporting ATPase
essential
no
synonyms
yvgX
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.1|Copper]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|transporters/ other], [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|resistance against toxic metals], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|CsoR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,441,121 -> 3,443,529

    The protein

    Catalyzed reaction/ biological activity

  • ATP H2O Cu1(In) = ADP phosphate Cu1(Out) (according to Swiss-Prot)

    • Protein family

  • Type IB subfamily (according to Swiss-Prot)

    • [SW|Domains]

  • two N-terminal soluble domains, CopAa and CopAb, connected by a short linker

    • Structure

  • [PDB|2RML] ( N-terminal soluble domain)
  • [PDB|4BBJ] (the protein from ''Legionella pneumophila'', 45% identity, 79% similarity) [Pubmed|24317491]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • [SW|Interactions]

  • [protein|search|CopA]-[protein|search|CopZ], for the transfer of the Cu(I) cluster [Pubmed|19751213]

    • Expression and Regulation

    Operon

  • ''[protein|search|copZ]-[protein|search|copA]'' [Pubmed|12779235]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|12779235]

    • Regulation

  • induced by copper ([protein|search|CsoR]) [Pubmed|18048925,12779235]

    • Regulatory mechanism

  • [protein|search|CsoR]: transcription repression [Pubmed|18048925]

    • Biological materials

    Mutant

  • MGNA-A490 (yvgX::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/490 NBRP B. subtilis, Japan]

    • Labs working on this gene/protein

  • [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

    • References

    Reviews

  • 19824702,23046649

    • Original publications

  • 19751213,11922674,12590580,14663075,12779235,12644235,18048925,14514665,14711369,19378562,15212800,20233928,24317491,22531974,22077885