gntK [Fri Sep 18 2015 17:39:20 GMT+0200 (CEST)]

gluconokinase

locus: BSU40060

pI: 5.00

mw: 56.00 kDa

function: gluconate utilization

product: gluconokinase

essential: no

ec: 2.7.1.12

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.13|Utilization of gluconate]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon], [SW|CcpA regulon], [SW|GntR regulon]

The protein

Catalyzed reaction/ biological activity

• ATP D-gluconate = ADP 6-phospho-D-gluconate (according to Swiss-Prot)

Protein family

• FGGY kinase family (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|gntR]-[protein|search|gntK]-[protein|search|gntP]-[protein|search|gntZ]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10746760 PubMed1][http://www.ncbi.nlm.nih.gov/sites/entrez/3020045 PubMed2]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|3020045]

Regulation

• induced by gluconate ([protein|search|GntR]) [Pubmed|3020045]
• repressed by glucose ([protein|search|CcpA]) [Pubmed|8370661]

Regulatory mechanism

• [protein|search|GntR]: transcription repression [Pubmed|3020045]
• [protein|search|CcpA]: transcription repression [Pubmed|10666464]
• [protein|search|AbrB]: transcription activation [Pubmed|20817675]

References

• 3011959,8288545,3037520,2537826,6322857,3020045,10746760,8370661,3020045,1659648,220817675