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folD [Fri Jan 29 2016 17:48:45 GMT+0100 (CET)]
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folD [Fri Jan 29 2016 17:48:45 GMT+0100 (CET)]

methylenetetrahydrofolate dehydrogenase (NADP)
Locus
BSU24310
Isoelectric point
5.00
Molecular weight
30.00 kDa
Function
formylation of Met-tRNA(fMet)
Product
methylenetetrahydrofolate dehydrogenase (NADP)
Essential
yes
E.C.
1.5.1.5
Synonyms
yqiA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Protein synthesis, modification and degradation → Translation → tRNA modification and maturation

    • Categories containing this gene/protein

  • translation, essential genes

    • This gene is a member of the following regulons

  • PurR regulon

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,528,404 -> 2,529,255

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • 5,10-methylenetetrahydrofolate NADP = 5,10-methenyltetrahydrofolate NADPH (according to Swiss-Prot)

    • Protein family

  • tetrahydrofolate dehydrogenase/cyclohydrolase family (according to Swiss-Prot)

    • Structure

  • 1B0A (from E. coli, 52% identity) PubMed

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • nusB-folD PubMed

    • Regulation

  • repressed in the presence of purine nucleotides (PurR) PubMed

    • Regulatory mechanism

  • PurR: transcription repression (molecular inducer: PRPP) PubMed

    • References

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