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folD [Fri Jan 29 2016 17:48:45 GMT+0100 (CET)]
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folD [Fri Jan 29 2016 17:48:45 GMT+0100 (CET)]

methylenetetrahydrofolate dehydrogenase (NADP)
locus
BSU24310
pI
5.00
mw
30.00 kDa
function
formylation of Met-tRNA(fMet)
product
methylenetetrahydrofolate dehydrogenase (NADP)
essential
yes
ec
1.5.1.5
synonyms
yqiA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]

    • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|PurR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,528,404 -> 2,529,255

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • 5,10-methylenetetrahydrofolate NADP = 5,10-methenyltetrahydrofolate NADPH (according to Swiss-Prot)

    • Protein family

  • tetrahydrofolate dehydrogenase/cyclohydrolase family (according to Swiss-Prot)

    • Structure

  • [PDB|1B0A] (from ''E. coli'', 52% identity) [Pubmed|10386884]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|nusB]-[protein|search|folD]'' [Pubmed|2536750,11591660]

    • Regulation

  • repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|2536750,11591660]

    • Regulatory mechanism

  • [protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750,11591660]

    • References

  • 11591660,19171795,11591660,19171795,10386884