ykuQ [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

similar to tetrahydrodipicolinate succinylase

locus: BSU14180

pI: 4.68

mw: 24.00 kDa

function: biosynthesis of lysine and peptidoglycan

product: similar to tetrahydrodipicolinate succinylase

essential: yes

ec: 2.3.1.89

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.7|Biosynthesis/ acquisition of lysine/ threonine/ based on similarity]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|essential genes], [SW|biosynthesis/ acquisition of amino acids]

Gene

Coordinates on the chromosome (coding sequence): 1,488,973 -> 1,489,683

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• Acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H₂O = CoA + L-2-acetamido-6-oxoheptanedioate (according to Swiss-Prot)

Protein family

• transferase hexapeptide repeat family (according to Swiss-Prot)

Structure

• [PDB|3R8Y] (from ''Bacillus anthracis'', 80% identity, 96% similarity)