SubtiBank SubtiBank
ykuQ
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ykuQ

similar to tetrahydrodipicolinate succinylase
locus
BSU_14180
pI
4.68
mw
24.84 kDa
protein length
236 aa Sequence Blast
gene length
711 bp Sequence Blast
function
biosynthesis of lysine and peptidoglycan
product
similar to tetrahydrodipicolinate succinylase
essential
yes
ec
2.3.1.89
synonyms
dapH
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.7|Biosynthesis/ acquisition of lysine/ threonine/ based on similarity]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    1,488,973 1,489,683

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O --> CoA + L-2-acetamido-6-oxoheptanedioate (according to UniProt)

    • Protein family

  • [SW|Transferase hexapeptide repeat family] (according to UniProt)

    • Structure

  • [PDB|3R8Y] (from ''Bacillus anthracis'', 80% identity, 96% similarity)

    • Expression and Regulation

    Operons

    genes
    [gene|716FE06124544C05CC34BA2E643B4DBD27F04998|ykuQ]-[gene|D6F1906CE8386F78F451D6B794F74DE4AD25AC9C|ykuR]-[gene|3E7E0342AA86AFCC95F5CD5BEA5B10166DCE2721|ykuS]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-B340 (ykuQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1339 NBRP B. subtilis, Japan]