ABC transporter for guanosine (ATP-binding protein)
function
uptake of guanosine
product
ABC transporter for guanosine
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.1|Uptake of carbon sources][category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon]Gene
Coordinates on the chromosome (coding sequence)
3,241,085 -> 3,242,617
Phenotypes of a mutant
a ''[protein|search|nupO] [protein|search|nupG]'' double mutant is unable to utilize externally provided guanosine [Pubmed|21926227]defective in the the ability to support the growth of ''Synechococcus leopoliensis'' CCAP1405/1 on agar media [Pubmed|25875741]The protein
Protein family
[SW|ABC transporter] family (according to Swiss-Prot)[SW|Localization]
associated to the membrane (via [protein|search|NupP]-[protein|search|NupQ]) [Pubmed|10092453][SW|Interactions]
[protein|search|NupO]-([protein|search|NupP]-[protein|search|NupQ]) [Pubmed|10092453]Expression and Regulation
Operon
''[protein|search|nupN]-[protein|search|nupO]-[protein|search|nupP]-[protein|search|nupQ]'' [Pubmed|21926227][SW|Sigma factor]
[protein|search|SigA] [Pubmed|21926227]Regulation
repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455,21699902,21926227]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|12618455,21699902,21926227]References
10092453,21926227,12618455,25875741 
