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nupO [2017-08-24 18:09:51]
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nupO [2017-08-24 18:09:51]

ABC transporter for guanosine (ATP-binding protein)
locus
BSU31550
pI
7.50
mw
56.13 kDa
protein length
510 aa Sequence Blast
gene length
1530 bp Sequence Blast
function
uptake of guanosine
product
ABC transporter for guanosine
essential
no
synonyms
yufO
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.1|Uptake of carbon sources]
  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,241,085 → 3,242,617

    Phenotypes of a mutant

  • a ''[gene|71546D1508EF17A208332E162CAE2C299987A569|nupO] [gene|C333F405F597FF260FFA0EC616B8CF6BF454815B|nupG]'' double mutant is unable to utilize externally provided guanosine [Pubmed|21926227]
  • defective in the the ability to support the growth of ''Synechococcus leopoliensis'' CCAP1405/1 on agar media [Pubmed|25875741]

    • The protein

    Protein family

  • [SW|ABC transporter] family (according to Swiss-Prot)

    • [SW|Localization]

  • associated to the membrane (via [protein|0BB235F189D30C9BE798560C31DA59FF0112CFD9|NupP]-[protein|7A80910F4E62BA15DE93FFC70E1908FB5CB9542D|NupQ]) [Pubmed|10092453]

    • Expression and Regulation

    Operons

    genes
    [gene|19BA45BD691BBA4B23C4741C63DB729AA5D30FDA|nupN]-[gene|71546D1508EF17A208332E162CAE2C299987A569|nupO]-[gene|0BB235F189D30C9BE798560C31DA59FF0112CFD9|nupP]-[gene|7A80910F4E62BA15DE93FFC70E1908FB5CB9542D|nupQ]
    description
    [Pubmed|21926227]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|21926227], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|12618455,21699902,21926227], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]

    • regulation

  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455,21699902,21926227]
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    Biological materials

    Mutant

  • MGNA-B554 (yufO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1553 NBRP B. subtilis, Japan]

    • References

  • 10092453,21926227,12618455,25875741