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penP [2019-01-30 22:44:38]
function
resistance to beta-lactam antibiotics
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]Gene
Coordinates
2,048,533 2,049,453
The protein
Catalyzed reaction/ biological activity
A beta-lactam + H2O = a substituted beta-amino acid (according to Swiss-Prot)Structure
[PDB|3KGM] (from ''B. licheniformis'', 58% identity, 79% similarity)[SW|Localization]
extracellular (signal peptide) [Pubmed|18957862]Expression and Regulation
Operons
genes
[gene|713BAB7190E1F86C55103049B29072F00E0DFFB3|penP]
description
[Pubmed|22383849]
view in new tabBiological materials
Mutant
BKE18800 ([gene|713BAB7190E1F86C55103049B29072F00E0DFFB3|penP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE18800 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAGGCCTCCTCATTCAA, downstream forward: _UP4_TAATATGTTTAGCCTTTTGCBKK18800 ([gene|713BAB7190E1F86C55103049B29072F00E0DFFB3|penP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK18800 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAGGCCTCCTCATTCAA, downstream forward: _UP4_TAATATGTTTAGCCTTTTGCReferences