penP [2017-8-11 16:0:3]

beta-lactamase

locus: BSU18800

pI: 9.21

mw: 33.29 kDa

protein length: 306 aa

gene length: 918 bp

function: resistance to beta-lactam antibiotics

product: beta-lactamase

essential: no

ec: 3.5.2.6

synonyms

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
• [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

Gene

Coordinates: 2,048,533 → 2,049,453

The protein

Catalyzed reaction/ biological activity

• A beta-lactam + H₂O = a substituted beta-amino acid (according to Swiss-Prot)

Structure

• [PDB|3KGM] (from ''B. licheniformis'', 58% identity, 79% similarity)

[SW|Localization]

• extracellular (signal peptide) [Pubmed|18957862]

Expression and Regulation

Operons

• genes: [gene|713BAB7190E1F86C55103049B29072F00E0DFFB3|penP]
  description: [Pubmed|22383849]

References

• 18957862