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acoR [2018-08-01 12:16:18]
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acoR [2018-08-01 12:16:18]

transcriptional activator of the acoA-acoB-acoC-acoL operon
locus
BSU08100
pI
7.88
mw
66.98 kDa
protein length
605 aa Sequence Blast
gene length
1815 bp Sequence Blast
function
regulation of acetoin utilization
product
transcriptional activator (for SigL-dependent promoter)
essential
no
synonyms
yfjG, yzcB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.2|Utilization of acetoin]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

    • Gene

    Coordinates
    883,758 → 885,575

    The protein

    Protein family

  • [SW|Transcription factors activating transcription at SigL-dependent promoters]

    • Expression and Regulation

    Operons

    genes
    [gene|706864AAF36684AD5E46F30E9EB76315AB412700|acoR]-[gene|4A4A533542E47DE8114B697FADE4CB581E5FB66E|sspH]
    description
    [Pubmed|11274109]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|22900538], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|12850135], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

    • regulation

  • repressed by glucose (3.7-fold) ([protein|search|CcpA]) [Pubmed|12850135]
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    Biological materials

    Mutant

  • MGNA-C352 (acoR::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2350 NBRP B. subtilis, Japan]
  • 1A912 ( ''acoR''::''kan''), [Pubmed|16585774], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A912&Search=1A912 BGSC] and in [SW|Jörg Stülke]'s lab
  • BKE08100 (Δ[gene|706864AAF36684AD5E46F30E9EB76315AB412700|acoR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE08100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCTTGATCGCTCCTC, downstream forward: _UP4_TAAAGCATACTTCCTTCAGG
  • BKK08100 (Δ[gene|706864AAF36684AD5E46F30E9EB76315AB412700|acoR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK08100 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCTTGATCGCTCCTC, downstream forward: _UP4_TAAAGCATACTTCCTTCAGG

    • Labs working on this gene/protein

  • [SW|Michel Debarbouille], Pasteur Institute, Paris, France [http://www.pasteur.fr/ip/easysite/go/03b-00000m-0ob/recherche/departements-scientifiques/microbiologie/unites-et-groupes/unite-de-biologie-des-bacteries-pathogenes-a-gram-positif/les-membres-de-l-equipe Homepage]

    • References

  • 11274109,10368162,22900538,12850135,21906631