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pgcA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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pgcA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)
Locus
BSU09310
Isoelectric point
4.00
Molecular weight
62.00 kDa
Function
interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate
Product
alpha-phosphoglucomutase
Essential
no
E.C.
5.4.2.2
Synonyms
yhxB, gtaC, gtaE

Genomic Context

      
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Categories containing this gene/protein

Categories containing this gene/protein

Gene

Coordinates on the chromosome (coding sequence)
1,006,774 -> 1,008,519

Phenotypes of a mutant

  • cells are bent and distended due to the lack of glucolipids PubMed
  • the inactivation of pgcA suppresses the poor and filamentous growth of the yvcL zapA double mutant PubMed
  • inactivation of pgcA reduces sporulation efficiency to 0.1% that of wild type cells; smaller and wider mother cells with small forespores PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (according to Swiss-Prot)
  • Protein family

  • phosphohexose mutase family (according to Swiss-Prot)
  • Modification

  • phosphorylated on ser/ thr/ tyr PubMed, PubMed
  • Additional information

  • PgcA inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)PubMed
  • Biological materials

    Mutant

  • GP1743: pgcA::aphA3, available in Jörg Stülke' lab
  • References

    Reviews

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    Original publications

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