pgcA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)

Locus: BSU09310

Isoelectric point: 4.00

Molecular weight: 62.00 kDa

Function: interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate

Product: alpha-phosphoglucomutase

Essential: no

E.C.: 5.4.2.2

Synonyms: yhxB, gtaC, gtaE

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of teichoic acid
• Metabolism → Lipid metabolism → Lipid metabolism/ other
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of teichoic acid
• Groups of genes → Phosphoproteins → Phosphorylation on either a Ser, Thr or Tyr residue

Categories containing this gene/protein

• cell wall synthesis, lipid metabolism/ other, phosphoproteins, sporulation/ other

Gene

Coordinates on the chromosome (coding sequence): 1,006,774 -> 1,008,519

Phenotypes of a mutant

• cells are bent and distended due to the lack of glucolipids PubMed
• the inactivation of pgcA suppresses the poor and filamentous growth of the yvcL zapA double mutant PubMed
• inactivation of pgcA reduces sporulation efficiency to 0.1% that of wild type cells; smaller and wider mother cells with small forespores PubMed

The protein

Catalyzed reaction/ biological activity

• Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (according to Swiss-Prot)

Protein family

• phosphohexose mutase family (according to Swiss-Prot)

Modification

• phosphorylated on ser/ thr/ tyr PubMed, PubMed

Additional information

• PgcA inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)PubMed

Biological materials

Mutant

• MGNA-B476 (yhxB::erm), available at the NBRP B. subtilis, Japan
• GP1743: pgcA::aphA3, available in Jörg Stülke' lab

References

Reviews

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Original publications

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