hemB [Tue Feb 09 2016 20:32:27 GMT+0100 (CET)]

porphobilinogen synthase

locus: BSU28130

pI: 4.00

mw: 36.00 kDa

function: heme biosynthesis

product: porphobilinogen synthase

essential: no

ec: 4.2.1.24

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors], [SW|phosphoproteins]

This gene is a member of the following [SW|regulons]

• [SW|PerR regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,874,202 -> 2,875,176

The protein

Catalyzed reaction/ biological activity

• 2 5-aminolevulinate = porphobilinogen 2 H₂O (according to Swiss-Prot)

Protein family

• ALADH family (according to Swiss-Prot)

Modification

• phosphorylated on Arg-217 [Pubmed|22517742]

[SW|Cofactors]

• zinc

Structure

• [PDB|1W5Q] (from ''Pseudomonas aeruginosa'', 48% identity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|hemA]-[protein|search|hemX]-[protein|search|hemC]-[protein|search|hemD]-[protein|search|hemB]-[protein|search|hemL]'' [Pubmed|1672867]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|1672867]

Regulation

• induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]

Regulatory mechanism

• [protein|search|PerR]: transcription repression [Pubmed|11532148]

References

• 10217486,11532148,1672867,4214010,804803,12926268,20823524,22517742