transcriptional repressor (ArsR family), cadA and czcD
function
regulation of resistance against toxic metal cations
product
transcriptional repressor (ArsR family)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.3|Zinc][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals][SW|Categories] containing this gene/protein
[SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|transcription factors and their control], [SW|resistance against toxic metals]Gene
Coordinates on the chromosome (coding sequence)
2,084,786 -> 2,085,109
The protein
Protein family
[SW|ArsR family]Effectors of protein activity
DNA-binding activity of CzrA is inactivated by high concentrations of toxic metal ions (induction)Structure
[PDB|1R1U] (the apo-repressor from ''Staph. aureus'', 49% identity, 82% similarity) [Pubmed|14568530][PDB|1R1V] (the Zn(II) form from ''Staph. aureus'', 49% identity, 82% similarity) [Pubmed|14568530][PDB|2KJB] (the DNA-bound form from ''Staph. aureus'', 49% identity, 82% similarity) [Pubmed|19822742]References
15948947,16430705,14568530,19822742,25213752,22007899 
