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yxeB [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]
hydroxamate siderophore ABC transporter (only ferrioxamine) (binding protein)
function
siderophore uptake
product
hydroxamate siderophore ABC transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|acquisition of iron], [SW|iron metabolism]This gene is a member of the following [SW|regulons]
[SW|Fur regulon]Gene
Coordinates on the chromosome (coding sequence)
4,067,183 -> 4,068,148
Phenotypes of a mutant
no growth with the xenosiderophore ferrioxamine E as single source of iron [Pubmed|23220087]The protein
Protein family
bacterial solute-binding protein 8 family (according to Swiss-Prot)[SW|Localization]
extracellular (signal peptide) [Pubmed|18957862]membrane, lipid modification as retention signal [Pubmed|18763711][SW|Interactions]
[protein|search|FhuC]-([protein|search|FhuB]-[protein|search|FhuG])-([protein|search|FhuD]-[protein|search|YxeB]) [Pubmed|10092453]Expression and Regulation
Operon
''[protein|search|yxeB]Regulation
repressed unless the cells enter an iron starvation ([protein|search|Fur]) [Pubmed|12354229]Regulatory mechanism
[protein|search|Fur]: transcription repression [Pubmed|12354229]References
10092453,16672620,12354229,18957862,18763711,23220087 
