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ysbA [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
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ysbA [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

putative pyruvate transporter
locus
BSU28910
pI
9.00
mw
15.00 kDa
function
uptake of pyruvate
product
putative pyruvate transporter
essential
no
synonyms
lrgA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.4|Transporter for organic acids]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|membrane proteins], [SW|utilization of specific carbon sources], [SW|transporters/ other]

    • This gene is a member of the following [SW|regulons]

  • [SW|Kre regulon], [SW|CcpA regulon], [SW|LytT regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,955,209 -> 2,955,649

    Phenotypes of a mutant

  • no growth with pyruvate as the single carbon source [Pubmed|27422364]
  • ''[SW|ysbA]-[SW|ysbB]'' mutant is delayed in pellicle formation [Pubmed|26060272]
  • a ''[SW|ywbH]-[SW|ywbG] [SW|yxaK]-[SW|yxaC] [SW|ysbA]-[SW|ysbB]'' triple mutant is severely delayed in pellicle formation [Pubmed|26060272]

    • The protein

    Protein family

  • LrgA subfamily (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|ysbA]-[protein|search|ysbB]'' [Pubmed|21815947]

    • Regulation

  • induced by acetate [Pubmed|26060272]
  • induced by pyruvate [SW|LytT] [Pubmed|27422364]
  • subject to catabolite repression [SW|CcpA] [Pubmed|27422364]

    • Regulatory mechanism

  • [SW|LytT]: transcription activation [Pubmed|27422364]
  • [SW|CcpA]: transcription repression (likely) [Pubmed|27422364]

    • Additional information

  • the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]
  • the expression of the ''[protein|search|ysbA]-[protein|search|ysbB]'' operon is strongly increased in a '[protein|search|cshA]' mutant [PubMed|23175651]
  • the ''[protein|search|ysbA]-[protein|search|ysbB]'' operon is strongly upregulated in a ''[SW|kre]'' mutant [Pubmed|26110430]

    • Biological materials

    Mutant

  • GP1554 (''[protein|search|ysbA]-[protein|search|ysbB]''::''spc''), available in [SW|Jörg Stülke]'s lab

    • References

    Reviews

  • 27511628

    • Original publications

  • 26060272,23175651,21815947,15659658,17452642,26110430,27422364