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prsA [2019-06-26 10:42:05]
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prsA [2019-06-26 10:42:05]

lipoprotein, post-translocational folding of exported proteins (post-translocation molecular chaperone)
locus
BSU09950
pI
9.12
mw
32.36 kDa
protein length
292 aa Sequence Blast
gene length
879 bp Sequence Blast
function
protein folding
product
post-translocation molecular chaperone
essential
yes
ec
5.2.1.8
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    1,070,364 1,071,242

    Phenotypes of a mutant

  • essential [Pubmed|20487272,12682299]
  • the mutant is viable in the presence of elevated concentrations of Mg2+ [Pubmed|20487272]

    • The protein

    Catalyzed reaction/ biological activity

  • catalyses the post-translocational folding of exported proteins [Pubmed|20487272], required for folding of [[penicillin-binding proteins]] ([protein|3B4F035535D6504405567E7C44E72902A11F7447|PbpA], [protein|EBEFF9E0A524DCDA19382E5401B923B805E4C559|PbpB], [protein|5BBA2769A9C0EDB56625F008A55470C2E2885AA4|PbpC], [protein|E50D4B30C2A0987A356C988AF8A4951C0CDF6C06|PbpD]) [Pubmed|20487272]

    • Protein family

  • PpiC domain (according to Swiss-Prot)

    • Modification

  • PrsA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure [Pubmed|22303020]

    • Structure

  • [PDB|1ZK6]

    • [SW|Localization]

  • membrane associated (lipoprotein) [Pubmed|22303020]
  • distinct spots organized in a helical pattern along the cell membrane [Pubmed|20487272]

    • Expression and Regulation

    Operons

    genes
    [gene|6EE13E61A218A6D52BAC83A1145B0B96961CE289|prsA]
    description
    [Pubmed|22383849]

    additional information

  • [protein|search|PrsA] is subject to degradation by [protein|search|WprA] and other extracellular proteases [PubMed|24362423]
    • view in new tab

    References

    Reviews

  • 25212246,28724440

    • Original publications

  • 12634326,14976191,11807061,10096076,18763711,10871614,20487272,22303020,24362423,25525259