aspartokinase I (alpha and beta subunits)
function
biosynthesis of lysine and peptidoglycan
product
aspartokinase I (alpha and beta subunits)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|biosynthesis/ acquisition of amino acids], [SW|Biosynthesis of cell wall components], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|SigK regulon]Gene
Coordinates on the chromosome (coding sequence)
1,747,123 -> 1,748,337
The protein
Catalyzed reaction/ biological activity
ATP L-aspartate = ADP 4-phospho-L-aspartate (according to Swiss-Prot) Protein family
aspartokinase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|LysC]Effectors of protein activity
inhibited by diaminopimelic acid [Pubmed|2152900]Structure
[PDB|1SFT] (from ''Geobacillus stearothermophilus'', 57% identity) [Pubmed|9063881]Expression and Regulation
Operon
''[SW|spoVFA]-[SW|spoVFB]-[protein|search|asd]-[protein|search|dapG]-[protein|search|dapA]'' [Pubmed|8098035]''[protein|search|asd]-[protein|search|dapG]-[protein|search|dapA]'' [Pubmed|8098035][SW|Sigma factor]
''[SW|spoVFA]'': [protein|search|SigK] [Pubmed|15699190,8098035]''[protein|search|asd]'': [protein|search|SigA] [Pubmed|8098035]References
Reviews
Original publications
8345520,2153658,15699190,8098035,2152900,9063881 
