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dapG [2019-08-01 11:21:14]
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dapG [2019-08-01 11:21:14]

aspartokinase I (alpha and beta subunits)
locus
BSU_16760
pI
5.71
mw
42.82 kDa
protein length
404 aa Sequence Blast
gene length
1215 bp Sequence Blast
function
biosynthesis of lysine and peptidoglycan
product
aspartokinase I (alpha and beta subunits)
essential
yes
ec
2.7.2.4
synonyms
lssD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    1,747,123 1,748,337

    Phenotypes of a mutant

  • essential [Pubmed|28189581]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + L-aspartate = ADP + 4-phospho-L-aspartate (according to Swiss-Prot)

    • Protein family

  • aspartokinase family (with [protein|F7B947938FB40E54D89A719E9610C5A4AA400674|LysC] and [protein|548E92526BC00999031D6EDE43FE061CE0448AFC|ThrD], according to UniProt)

    • Paralogous protein(s)

  • [protein|F7B947938FB40E54D89A719E9610C5A4AA400674|LysC]

    • [SW|Domains]

  • [SW|ACT domain] (aa 344 ... 404) (according to the Interpro database)

    • Effectors of protein activity

  • inhibited by diaminopimelic acid [Pubmed|2152900]

    • Structure

  • [PDB|1SFT] (from ''Geobacillus stearothermophilus'', 57% identity) [Pubmed|9063881]

    • Expression and Regulation

    Operons

    genes
    [gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
    description
    [Pubmed|8098035]

    sigma factors

  • [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK regulon]
  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8098035], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
    • view in new tab

    genes
    [gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]-[gene|4D93A13DB9DC55A49525BFF4FD589F4FF67D50E8|spoVFB]-[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
    description
    [Pubmed|8098035]

    sigma factors

  • [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK regulon]

    • regulation

  • expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|15699190,8098035]
    • view in new tab

    References

    Reviews

  • 19946135,22079167

    • Original publications

  • 8345520,2153658,15699190,8098035,2152900,9063881,28189581