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dapG [2019-05-07 15:41:30]
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dapG [2019-05-07 15:41:30]

aspartokinase I (alpha and beta subunits)
locus
BSU16760
pI
5.71
mw
42.82 kDa
protein length
404 aa Sequence Blast
gene length
1215 bp Sequence Blast
function
biosynthesis of lysine and peptidoglycan
product
aspartokinase I (alpha and beta subunits)
essential
yes
ec
2.7.2.4
synonyms
lssD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    1,747,123 1,748,337

    Phenotypes of a mutant

  • essential [Pubmed|28189581]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + L-aspartate = ADP + 4-phospho-L-aspartate (according to Swiss-Prot)

    • Protein family

  • aspartokinase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|F7B947938FB40E54D89A719E9610C5A4AA400674|LysC]

    • [SW|Domains]

  • [SW|ACT domain] (aa 344 ... 404) (according to the Interpro database)

    • Effectors of protein activity

  • inhibited by diaminopimelic acid [Pubmed|2152900]

    • Structure

  • [PDB|1SFT] (from ''Geobacillus stearothermophilus'', 57% identity) [Pubmed|9063881]

    • Expression and Regulation

    Operons

    genes
    [gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
    description
    [Pubmed|8098035]

    sigma factors

  • [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK regulon]
  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8098035], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
    • view in new tab

    genes
    [gene|3DA80060554B78E9DC2189CECB78680095B08B32|spoVFA]-[gene|4D93A13DB9DC55A49525BFF4FD589F4FF67D50E8|spoVFB]-[gene|564A2F43F8AABE97FC8F0B1B3382A9F31F02FA18|asd]-[gene|6D6718AC72C9D86EDE16B191EDAB3ABA488B689B|dapG]-[gene|00B4CA4E25858A56F9D4E0ADEE2643F203FEC613|dapA]
    description
    [Pubmed|8098035]

    sigma factors

  • [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]: sigma factor, [Pubmed|15699190,8098035], in [regulon|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK regulon]

    • regulation

  • expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|15699190,8098035]
    • view in new tab

    References

    Reviews

  • 19946135,22079167

    • Original publications

  • 8345520,2153658,15699190,8098035,2152900,9063881,28189581