blue light sensor, positive regulation of SigB activity under conditions of blue light
function
control of SigB activity
product
blue light receptor, flavoprotein
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors][SW|Categories] containing this gene/protein
[SW|sigma factors and their control]This gene is a member of the following [SW|regulons]
[SW|Spx regulon]Gene
Coordinates on the chromosome (coding sequence)
3,106,210 -> 3,106,995
The protein
Catalyzed reaction/ biological activity
mediates light-dependent stimulation of [protein|search|RsbT] kinase activity [Pubmed|23416074]Paralogous protein(s)
[protein|search|RsbR], [SW|RsbRB], [SW|RsbRC], [SW|RsbRD], [protein|search|YtvA][SW|Domains]
[SW|PAS domain]LOV domain, STAS domain[SW|Cofactors]
FMNEffectors of protein activity
[protein|search|YtvA]-dependent light activation of the [protein|search|SigB] stress response is positively and negatively regulated by [SW|RsbRA] and [SW|RsbRB], respectively [Pubmed|22287516]Structure
[PDB|2PR5] (dark), [PDB|2PR6] (light), [PDB|2MWG][SW|Interactions]
forms dimers [Pubmed|20800068][protein|search|YtvA]-[SW|RsbRA] [Pubmed|11157946][protein|search|YtvA]-[SW|RsbRD] [Pubmed|11157946]part of the [SW|stressosome] [Pubmed|23416074]Expression and Regulation
Regulation
induced under conditions of disulfide stress ([protein|search|Spx]) [Pubmed|16923906]Regulatory mechanism
[protein|search|Spx]: transcription activation [Pubmed|16923906]Biological materials
Mutant
1A965 ( ''ytvA''::''erm''), [Pubmed|11157946], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A965&Search=1A965 BGSC]Expression vector
pGP2685, expression of His-[protein|search|YtvA] in ''E. coli'' (based on [SW|pGP570]), available in [SW|Jörg Stülke]'s labLabs working on this gene/protein
[SW|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]References
Reviews
18400553,21822294,26189730 Original publications
27203230,19581299,16923906,17575448,17764689,17443319,17200735,16923909,16797012,16022561,15339223,11964249,11157946,19891470,20062844,19783626,20800068,22247770,23047813,23416074,23456923,23817467,21259411,21388385,21410163,21851109,22287516,23861663,23828427,23900620,23940057,24171435,24278408,25211155,26402155