high-affinity ABC transporter for zinc (ATP-binding protein)
product
ABC transporter for zinc (ATP-binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.6|Uptake of ions][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.3|Zinc][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|Zur regulon]Gene
Coordinates on the chromosome (coding sequence)
309,347 -> 310,042
Phenotypes of a mutant
reduced genetic competence, can be rescued by the addition of excess zinc [Pubmed|21813502]reduced expression of the ''[SW|comFA]-[SW|comFB]-[SW|comFC]-[protein|search|yvyF]-[protein|search|flgM]-[protein|search|yvyG]-[protein|search|flgK]-[protein|search|flgL]'' operon [Pubmed|21813502]The protein
Protein family
[SW|ABC transporter] domain (according to Swiss-Prot)Structure
[PDB|4YMS] (from ''Caldanaerobacter subterraneus'', 31% identity) [Pubmed|25848002]Expression and Regulation
Operon
''[protein|search|znuA]-[protein|search|znuC]-[protein|search|znuB]'' [Pubmed|9811636][SW|Sigma factor]
[protein|search|SigA] [Pubmed|12426338]Regulation
induced by zinc starvation ([protein|search|Zur]) [Pubmed|12426338]Regulatory mechanism
[protein|search|Zur]: transcription repression in the presence of zinc [Pubmed|12426338]part of the second wave of induction upon zinc depletion [Pubmed|27561249]References
12426338,9811636,10092453,21813502,12426338,25848002,27561249 
