two-component sensor kinase, chemotactic signal modulator
function
chemotactic signal modulator
product
two-component sensor kinase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.1|Soluble signalling proteins][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.6|Other proteins required for efficient pellicle biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|protein modification], [SW|transcription factors and their control], [SW|motility and chemotaxis], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|DegU regulon], [SW|SigD regulon], [SW|Spo0A regulon]Gene
Phenotypes of a mutant
not essential for pellicle biofilm formation, but mutant is outcompeted by the wild-type strain when competed during pellicle formation [Pubmed|26122431]The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|search|CheY] and [protein|search|CheB] [Pubmed|11553614]Modification
autophosphorylation on a His residueEffectors of protein activity
phosphorylation of [protein|search|CheA] is stimulated by interaction with the complex of deaminated [protein|search|McpC]-[protein|search|CheD] [Pubmed|22931217]the kinase activity of [protein|search|CheA] is activated by chemoreceptors bound to [protein|search|CheD] [Pubmed|23226535][SW|Localization]
membrane (according to Swiss-Prot)localizes to the cell poles [Pubmed|21098025][SW|Interactions]
[protein|search|CheA]-[protein|search|McpB] [Pubmed|19864420][protein|search|CheA]-[protein|search|CheC] [Pubmed|11722727][protein|search|CheA]-[protein|search|CheY] [Pubmed|11553614][protein|search|CheA]-[protein|search|CheW] [Pubmed|25039821]Expression and Regulation
Operon
part of the [[fla-che operon]]''[protein|search|flgB]-[protein|search|flgC]-[protein|search|fliE]-[protein|search|fliF]-[protein|search|fliG]-[protein|search|fliH]-[protein|search|fliI]-[protein|search|fliJ]-[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|9657996,8157612,15175317]''[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|20233303][SW|Sigma factor]
''[protein|search|flgB]'': [protein|search|SigA] [Pubmed|9657996], [protein|search|SigD] [Pubmed|9657996]''[protein|search|ylxF]'': [protein|search|SigD] [Pubmed|20233303]Regulation
see [[fla-che operon]]Regulatory mechanism
see [[fla-che operon]]Biological materials
Mutant
1A797 ( ''cheA''::''cat''), [Pubmed|1938941], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A797&Search=1A797 BGSC]DS6887 (marker-less in NCIB3610) [Pubmed|25313396]Labs working on this gene/protein
[SW|Daniel Kearns]References
Reviews
Original publications
26122431,25313396,1938941,12123464,17908686,8866475,12094812,10094672,11722727,14651647,9657996,8157612,15175317,9721285,17850253,11553614,21098025,22931217,21515776,23226535,24386445,25039821 
