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opuE [Tue Mar 15 2016 15:00:06 GMT+0100 (CET)]
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opuE [Tue Mar 15 2016 15:00:06 GMT+0100 (CET)]

proline transporter
locus
BSU06660
pI
9.00
mw
53.00 kDa
function
compatible solute transport
product
proline transporter
essential
no
synonyms
yerK
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.1|Solute:sodium symporter family]
  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.7|Sodium-solute symporter]
  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.9|Uptake of compatible solutes]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|general stress proteins (controlled by SigB)], [SW|transporters/ other], [SW|coping with hyper-osmotic stress], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigB regulon], [SW|CcpA regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    726,840 -> 728,318

    Phenotypes of a mutant

  • strong growth disadvantage in high-salinity minimal media lacking proline [Pubmed|22685134]

    • The protein

    Protein family

  • solute:sodium symporter family (SSS family)

    • Paralogous protein(s)

  • [protein|search|PutP]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|opuE]'' [Pubmed|22383849]

    • [SW|Sigma factor]

  • [protein|search|SigB] [Pubmed|9701821]

    • Regulation

  • induced by stress ([protein|search|SigB]) [Pubmed|9701821]
  • induced by glucose ([protein|search|CcpA]) [Pubmed|22900538]

    • Regulatory mechanism

  • [protein|search|CcpA]: transcription activation [Pubmed|22900538]

    • Additional information

  • the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]

    • Biological materials

    Mutant

  • available in [SW|Erhard Bremer]'s lab [Pubmed|24142252]

    • Labs working on this gene/protein

  • [SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

    • References

  • 12884008,9701821,11902719,11902719,22685134,22900538,22383849,24142252,22139509,26728461