function
compatible solute transport
product
proline transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.1|Solute:sodium symporter family][category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.7|Sodium-solute symporter][category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.9|Uptake of compatible solutes][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|general stress proteins (controlled by SigB)], [SW|transporters/ other], [SW|coping with hyper-osmotic stress], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigB regulon], [SW|CcpA regulon]Gene
Coordinates on the chromosome (coding sequence)
726,840 -> 728,318
Phenotypes of a mutant
strong growth disadvantage in high-salinity minimal media lacking proline [Pubmed|22685134]The protein
Protein family
solute:sodium symporter family (SSS family)Paralogous protein(s)
[protein|search|PutP][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|opuE]'' [Pubmed|22383849][SW|Sigma factor]
[protein|search|SigB] [Pubmed|9701821]Regulation
induced by stress ([protein|search|SigB]) [Pubmed|9701821]induced by glucose ([protein|search|CcpA]) [Pubmed|22900538]Regulatory mechanism
[protein|search|CcpA]: transcription activation [Pubmed|22900538]Additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]Biological materials
Mutant
available in [SW|Erhard Bremer]'s lab [Pubmed|24142252]Labs working on this gene/protein
[SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]References
12884008,9701821,11902719,11902719,22685134,22900538,22383849,24142252,22139509 
