hisS [Mon Aug 31 2015 13:55:59 GMT+0200 (CEST)]

histidyl-tRNA synthetase

locus: BSU27560

pI: 5.23

mw: 47.00 kDa

function: translation

product: histidyl-tRNA synthetase

essential: yes

ec: 6.1.1.21

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|translation], [SW|essential genes]

This gene is a member of the following [SW|regulons]

• [SW|T-box]

Gene

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His) (according to Swiss-Prot)

Protein family

• class-II aminoacyl-tRNA synthetase family (according to Swiss-Prot)

Structure

• [PDB|1H4V] (from ''Thermus thermophilus'', 43% identity, 61% similarity) [Pubmed|11399074]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|hisS]-[protein|search|aspS]

Regulation

• induced by histidine or aspartate limitation ([protein|search|T-box]) [Pubmed|19258532]

Regulatory mechanism

• [protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]

References

• 19258532