repression of the hexuronate utilization operon (uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA)
function
regulation of hexuronate utilization
product
transcriptional repressor (LacI family)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|transcription factors and their control], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|ExuR regulon], [SW|SigE regulon]Gene
Coordinates on the chromosome (coding sequence)
1,308,802 -> 1,309,803
The protein
Protein family
[SW|LacI family]Effectors of protein activity
galacturonate acts as the molecular inducer [Pubmed|9882655]Expression and Regulation
Operon
''[protein|search|uxaC]-[protein|search|yjmB]-[protein|search|yjmC]-[protein|search|yjmD]-[protein|search|uxuA]-[protein|search|yjmF]-[protein|search|exuT]-[protein|search|exuR]-[protein|search|uxaB]-[protein|search|uxaA]'' [Pubmed|9882655]''[protein|search|yjmC]-[protein|search|yjmD]-[protein|search|uxuA]-[protein|search|yjmF]-[protein|search|exuT]-[protein|search|exuR]-[protein|search|uxaB]-[protein|search|uxaA]'' [Pubmed|9882655][SW|Sigma factor]
[protein|search|SigE] [Pubmed|15699190]''[protein|search|uxaC]'': [protein|search|SigA] [Pubmed|9882655]''[protein|search|yjmC]'': [protein|search|SigE] [Pubmed|9882655]Regulation
repressed by glucose ([protein|search|CcpA]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2]induced by galacturonate ([protein|search|ExuR]) [Pubmed|9882655]Regulatory mechanism
[protein|search|CcpA]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2][protein|search|ExuR]: reanscription repression in the absence of inducer [Pubmed|9882655]References
