csoR

transcription repressor of copZ-copA

Locus: BSU_33520

Isoelectric point: 7.30

Molecular weight: 11.34 kDa

Protein length: 101 aa

Gene length: 306 bp

Function: control of copper homeostasis

Product: transcription repressor

Essential: no

Synonyms: yvgZ

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Homeostasis → Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo) → Copper
• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
• Lifestyles → Coping with stress → Resistance against toxic metals
• Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue

Gene

Coordinates: 3,443,896 3,444,201

The protein

Protein family

• CsoR family (single member, according to UniProt)

Effectors of protein activity

• Cu(I) ions cause release of CsoR from its operator sites

Structure

• 4M1P (from Geobacillus thermodenitrificans, 59% identity) PubMed

Expression and Regulation

Operons

• Genes: csoR-copZ-copA
  Description: PubMed

Biological materials

Mutant

• MGNA-B604 (yvgZ::erm), available at the NBRP B. subtilis, Japan
• BKE33520 (csoR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGCGTACACCTCTGTTTA, downstream forward: _UP4_TAAAGCGTTTTTTATTGTAA
• BKK33520 (csoR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGCGTACACCTCTGTTTA, downstream forward: _UP4_TAAAGCGTTTTTTATTGTAA

Labs working on this gene/protein

• John Helmann, Cornell University, USA Homepage
• Mohamed Marahiel, Marburg University, Germany homepage

References

Reviews

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Original publications

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