malR [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

two-component response regulator, regulation of malate uptake

locus: BSU31530

pI: 5.98

mw: 26.00 kDa

function: regulation of malate uptake

product: two-component response regulator

essential: no

synonyms: yufM

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources], [SW|transcription factors and their control], [SW|phosphoproteins]

Gene

Coordinates on the chromosome (coding sequence): 3,238,751 -> 3,239,458

Phenotypes of a mutant

• unable to use malate as the single carbon source [Pubmed|12949159]

The protein

Modification

• phosphorylated by [protein|search|MalK] on an Asp residue

Effectors of protein activity

• phosphorylation likely affects DNA-binding activity

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|MalK]-[protein|search|MalR]

Expression and Regulation

Operon

• ''[protein|search|malR]'' [Pubmed|9274030]

Biological materials

Mutant

• GP1301 (cat), available in [SW|Stülke] lab

Labs working on this gene/protein

• [SW|Stephane Aymerich], Microbiology and Molecular Genetics, INRA Paris-Grignon, France

References

• 10094672,12949160,12949159,9274030