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pucE [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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pucE [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

xanthine dehydrogenase
locus
BSU32470
pI
6.13
mw
18.00 kDa
function
purine utilization
product
xanthine dehydrogenase
essential
no
synonyms
yurB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.1|Utilization of nucleotides]

    • [SW|Categories] containing this gene/protein

  • [SW|utilization of nucleotides]

    • This gene is a member of the following [SW|regulons]

  • [SW|PucR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,335,751 -> 3,336,272

    The protein

    Catalyzed reaction/ biological activity

  • Xanthine + NAD+ + H2O = urate + NADH (according to Swiss-Prot)

    • Structure

  • [PDB|1JRO] (from ''Rhodobacter capsulatus'', 43% identity, 58% similarity) [Pubmed|11796116]

    • Expression and Regulation

    Operon

  • ''[protein|search|pucA]-[protein|search|pucB]-[protein|search|pucC]-[protein|search|pucD]-[protein|search|pucE]'' [Pubmed|12823818]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|12029039]

    • Regulation

  • induced in the presence of purine nucleotides (effector: allantoin) ([protein|search|PucR]) [Pubmed|12029039]

    • Regulatory mechanism

  • [protein|search|PucR]: transcription activaton [Pubmed|12029039]

    • References

  • 11344136,12029039,12823818