ftsA [2019-04-15 18:59:12]

cell division protein, membrane anchor for FtsZ

Locus: BSU15280

Isoelectric point: 5.09

Molecular weight: 47.94 kDa

Protein length: 440 aa

Gene length: 1323 bp

Function: formation of Z-ring

Product: cell division protein

Essential: yes

Synonyms: spoIIN

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell division → Other genes
• Groups of genes → Essential genes
• Groups of genes → Membrane proteins

Gene

Coordinates: 1,596,474 1,597,796

Phenotypes of a mutant

• essential PubMed
• cells become elongated PubMed
• the ftsA mutation is synthetically lethal with a sepF mutation PubMed

The protein

Catalyzed reaction/ biological activity

• required for septum recruitment of SftA PubMed

Protein family

• ftsA/mreB family (according to Swiss-Prot)

Structure

• 3WQT (from Staphylococcus aureus, 31% identity) PubMed

Localization

• septal at the cell membrane (35% of the molecules) PubMed
• cytoplasma (65% of the molecules) PubMed
• septal localization depends on the proton motive force PubMed

Expression and Regulation

Operons

• Genes: ftsA-ftsZ
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigH: sigma factor, PubMed, in SigH regulon

  Regulatory mechanism

  • WalR: activation, in WalR regulon

  Regulation

  • activated by WalR PubMed

  Additional information

  • half-life of the ftsZ mRNA: 2.2 min PubMed

Biological materials

Mutant

• 1A787 ( ftsA::cat), PubMed, available at BGSC

References

Reviews

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Original Publications

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