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ftsA [2020-06-22 10:15:55]
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ftsA [2020-06-22 10:15:55]

cell division protein, membrane anchor for FtsZ
Locus
BSU_15280
Isoelectric point
5.09
Molecular weight
47.94 kDa
Protein length
440 aa Sequence Blast
Gene length
1323 bp Sequence Blast
Function
formation of Z-ring
Product
cell division protein, member of the divisome
Essential
no
Synonyms
spoIIN

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
1,596,474 1,597,796

Phenotypes of a mutant

  • essential PubMed
  • cells become elongated PubMed
  • the ftsA mutation is synthetically lethal with a sepF mutation PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • required for septum recruitment of SftA PubMed
  • Protein family

  • FtsA/MreB family (according to UniProt)
  • Structure

  • 3WQT (from Staphylococcus aureus, 31% identity) PubMed
  • Localization

  • septal at the cell membrane (35% of the molecules) PubMed
  • cytoplasma (65% of the molecules) PubMed
  • septal localization depends on the proton motive force PubMed
  • Expression and Regulation

    Operons

    Genes
    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigH: sigma factor, PubMed, in SigH regulon
  • Regulatory mechanism

  • WalR: activation, in WalR regulon
  • Regulation

  • activated by WalR PubMed
  • Additional information

  • half-life of the ftsZ mRNA: 2.2 min PubMed
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    Biological materials

    Mutant

  • 1A787 ( ftsA::cat), PubMed, available at BGSC
  • References

    Reviews

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    Original Publications

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