function
utilization of acetate, fatty acids
product
acetyl-CoA synthetase)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|utilization of lipids]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|CodY regulon]Gene
Coordinates on the chromosome (coding sequence)
3,038,213 -> 3,039,931
The protein
Catalyzed reaction/ biological activity
ATP acetate CoA = AMP diphosphate acetyl-CoA (according to Swiss-Prot) Protein family
ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)Modification
acetylated on Lys-549 by [protein|search|AcuA], this results in inactivation [Pubmed|18487328], deacetylated by [protein|search|SrtN] and [protein|search|AcuC] deacetylates (and thereby activates) [protein|search|AcsA] [Pubmed|19136592]Structure
[PDB|2P2F] (from ''Salmonella enterica'', 37% identity) [Pubmed|17497934]Expression and Regulation
Operon
''[protein|search|acsA]'' [Pubmed|7934817][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7913927]Regulation
repressed by glucose (4.5-fold) ([protein|search|CcpA]) [Pubmed|7913927,12850135]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455,18083814]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|7913927][protein|search|CodY]: transcription repression [Pubmed|12618455,18083814]Biological materials
Mutant
GP1212 (''acsA''::''kan''), available in [SW|Stülke] labReferences
Reviews
15316652,15491124,15221478 Original publications
7934817,7913927,18083814,17303131,12618455,19136592,18487328,12850135,16855235,22900538,17497934 
