kre [2017-8-11 16:0:3]

[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK] repressor, stimulates degradation of the [gene|search|comK ]mRNA

locus: BSU14020

pI: 10.17

mw: 17.75 kDa

protein length: 154 aa

gene length: 462 bp

function: control of [protein|search|ComK ]accumulation and of bistable competence gene expression

product: [protein|search|ComK ]repressor

essential: no

synonyms: ykyB

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

Gene

Coordinates: 1,474,560 → 1,475,024

The protein

Catalyzed reaction/ biological activity

• stimulates [protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK] mRNA degradation [Pubmed|26110430]
• controls stability of several mRNAs (see [SW|Kre regulon]) [Pubmed|26110430]

[SW|Localization]

• cytoplasm [Pubmed|26110430]

Expression and Regulation

Operons

• genes: [gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]
  description: [Pubmed|8169223]

  regulatory mechanism

  • [protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK]: repression, [Pubmed|26110430], in [regulon|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK regulon]

  regulation

  • repressed in competent cells ([SW|ComK]) [Pubmed|26110430]

Biological materials

Mutant

• MGNA-A764 (ykyB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/764 NBRP B. subtilis, Japan]
• PG479 (ykyB::erm), available in [SW|Leendert Hamoen]'s and [SW|Jörg Stülke]'s labs [Pubmed|26110430]
• GP2533 ([gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]::''erm''), available in [SW|Jörg Stülke]'s lab

References

Reviews

• 26110607

Original Publications

• 8169223,26110430