kre [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

ComK repressor, stimulates degradation of the comK mRNA

locus: BSU14020

pI: 10.00

mw: 17.00 kDa

function: control of ComK accumulation and of bistable competence gene expression

product: ComK repressor

essential: no

synonyms: ykyB

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

[SW|Categories] containing this gene/protein

• [SW|genetic competence]

This gene is a member of the following [SW|regulons]

• [SW|ComK regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,474,560 -> 1,475,024

The protein

Catalyzed reaction/ biological activity

• stimulates [SW|ComK] mRNA degradation [Pubmed|26110430]
• controls stability of several mRNAs (see [SW|Kre regulon]) [Pubmed|26110430]

[SW|Localization]

• cytoplasm [Pubmed|26110430]

Expression and Regulation

Operon

• ''[protein|search|kre]'' [Pubmed|8169223]

Regulation

• repressed in competent cells ([SW|ComK]) [Pubmed|26110430]

Regulatory mechanism

• [SW|ComK]: transcription repression [Pubmed|26110430]

Biological materials

Mutant

• MGNA-A764 (ykyB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/764 NBRP B. subtilis, Japan]

References

Reviews

• 26110607

Original Publications

• 8169223,26110430