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dnaE [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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dnaE [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

DNA polymerase III (alpha subunit), part of the replisome
Locus
BSU29230
Isoelectric point
6.02
Molecular weight
125.00 kDa
Function
DNA replication
Product
DNA polymerase III (alpha subunit)
Essential
yes
E.C.
2.7.7.7
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Categories containing this gene/protein

This gene is a member of the following regulons

Gene

Phenotypes of a mutant

  • essential PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
  • required for bacteriophage SPP1 replication PubMed
  • Protein family

  • DnaE subfamily (according to Swiss-Prot)
  • Structure

  • 3E0D (from Thermus aquaticus, 39% identity) PubMed
  • Localization

  • forms foci, the foci dissappear after the formation of DNA mismatches in a MutS-dependent manner or after DNA replication arrest PubMed
  • cytoplasm (according to Swiss-Prot)
  • Interactions

    Expression and Regulation

    Operon

  • dnaE (according to DBTBS)
  • Regulation

  • induced by DNA damage (LexA) PubMed
  • Regulatory mechanism

  • LexA: transcription repression PubMed
  • References

    Reviews

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    Original publications

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