pyridoxal-5-phosphate synthase (synthase domain)
function
pyridoxal-5-phosphate biosynthesis
product
pyridoxal-5-phosphate synthase (synthase domain)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.12|Biosynthesis of pyridoxal phosphate][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors], [SW|phosphoproteins], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
19,062 -> 19,946
Phenotypes of a mutant
auxotrophic for pyridoxal 5'-phosphate [Pubmed|14762015]inactivation of ''[SW|yaaD]'' reduces sporulation efficiency to 1.2% that of wild type cells [Pubmed|26735940]The protein
Protein family
pdxS/SNZ family (according to Swiss-Prot)Modification
phosphorylated on Arg-8 [Pubmed|22517742]phosphorylated on STY [Pubmed|16493705], [Pubmed|17726680]Structure
[PDB|2NV2] [protein|search|PdxS]-[protein|search|PdxT] complex [Pubmed|17159152][PDB|2NV1] [protein|search|PdxS] [Pubmed|17159152][SW|Interactions]
[protein|search|PdxS]-[protein|search|PdxT] [Pubmed|25473090,14762015,16030023,17159152]Expression and Regulation
Operon
''[protein|search|pdxS]-[protein|search|pdxT]'' [Pubmed|22383849]Regulation
negatively controlled by [SW|Spo0A] [Pubmed|14651647]repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647]Additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]References
15911615,14762015,25473090,14651647,17726680,16493705,16030023,19152323,17159152,22517742,15378759,25568319,26490441,16233205, 14585832 
