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glnR [2017-8-11 16:0:3]
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glnR [2017-8-11 16:0:3]

transcriptional repressor (MerR family) of the glnR-glnA operon
Locus
BSU17450
Isoelectric point
9.73
Molecular weight
15.69 kDa
Protein length
135 aa Sequence Blast
Gene length
405 bp Sequence Blast
Function
regulation of glutamine synthesis
Product
transcription repressor (MerR family)
Essential
no
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
1,877,959 → 1,878,366

The protein

Protein family

Cofactors

  • feedback-inhibited GlnA PubMed
  • Effectors of protein activity

  • activity is enhanced upon interaction of the C-terminal domain with GlnA PubMed
  • Structure

  • 4R4E (the GlnR-DNA complex) PubMed
  • Expression and Regulation

    Operons

    Genes
    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • TnrA: repression, PubMed, in TnrA regulon
  • GlnR: repression, in complex with GlnA, in GlnR regulon
  • Regulation

  • expressed in the absence of glutamine (GlnR) PubMed
  • the mRNA is processed between glnR and glnA by RNase Y, this requires the YmcA-YlbF-YaaT complex PubMed
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    Description

    Regulation

  • the mRNA is processed between glnR and glnA by RNase Y, this requires the YmcA-YlbF-YaaT complex PubMed
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    Genes
    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • TnrA: repression, PubMed, in TnrA regulon
  • GlnR: repression, in complex with GlnA, in GlnR regulon
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    Biological materials

    Mutant

  • BP148 (del(glnR-glnA)::cat), available in Fabian Commichau's lab
  • LacZ fusion

  • pGP189 (in pAC7), available in Jörg Stülke's lab
  • Labs working on this gene/protein

  • Susan Fisher, Boston, USA homepage
  • References

    Reviews

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    Original publications

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