glnR [2017-8-11 16:0:3]

transcriptional repressor (MerR family) of the glnR-glnA operon

Locus: BSU17450

Isoelectric point: 9.73

Molecular weight: 15.69 kDa

Protein length: 135 aa

Gene length: 405 bp

Function: regulation of glutamine synthesis

Product: transcription repressor (MerR family)

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of glutamate/ glutamine/ ammonium assimilation
• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other

Gene

Coordinates: 1,877,959 → 1,878,366

The protein

Protein family

• MerR family

Cofactors

• feedback-inhibited GlnA PubMed

Effectors of protein activity

• activity is enhanced upon interaction of the C-terminal domain with GlnA PubMed

Structure

• 4R4E (the GlnR-DNA complex) PubMed

Expression and Regulation

Operons

• Genes: glnR-glnA
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • TnrA: repression, PubMed, in TnrA regulon
  • GlnR: repression, in complex with GlnA, in GlnR regulon

  Regulation

  • expressed in the absence of glutamine (GlnR) PubMed
  • the mRNA is processed between glnR and glnA by RNase Y, this requires the YmcA-YlbF-YaaT complex PubMed

• Genes: ynbA-ynbB-glnR-glnA
  Description: PubMed

  Regulation

  • the mRNA is processed between glnR and glnA by RNase Y, this requires the YmcA-YlbF-YaaT complex PubMed

• Genes: glnR
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • TnrA: repression, PubMed, in TnrA regulon
  • GlnR: repression, in complex with GlnA, in GlnR regulon

Biological materials

Mutant

• BP148 (del(glnR-glnA)::cat), available in Fabian Commichau's lab

LacZ fusion

• pGP189 (in pAC7), available in Jörg Stülke's lab

Labs working on this gene/protein

• Susan Fisher, Boston, USA homepage

References

Reviews

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Original publications

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