RNA polymerase sigma factor SigO (with RsoA)
function
RNA polymerase sigma factor
product
co-sigma factor with RsoA
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.2|Sigma factors][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.1|Sigma factors][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.3|Acid stress proteins (controlled by YvrI-YvrHa)][SW|Categories] containing this gene/protein
[SW|transcription], [SW|sigma factors and their control], [SW|acid stress proteins (controlled by SigO-RsoA)]This gene is a member of the following [SW|regulons]
[SW|YvrHb regulon], [SW|SigO-RsoA regulon]Gene
Coordinates on the chromosome (coding sequence)
3,409,462 -> 3,409,992
The protein
[SW|Domains]
contains a DNA-binding helix-turn-helix motif (HTH) and the region 4.2 of Sigma factors [Pubmed|19940246][SW|Interactions]
[protein|search|SigO]-[protein|search|RpoB] [Pubmed|19940246][protein|search|SigO]-[SW|RsoA] [Pubmed|19940246][SW|RsiO]-[SW|SigO], at neutral pH, to inhibit [SW|SigO] activity [Pubmed|26651345]Expression and Regulation
Operon
''[protein|search|sigO]-[SW|rsoA]'' [Pubmed|19047353][SW|Sigma factor]
[protein|search|SigO]-[SW|RsoA] [Pubmed|19047353]Regulation
induced by acidic growth conditions [Pubmed|19047353]Regulatory mechanism
activated by [SW|YvrHb] [Pubmed|16306698]Labs working on this gene/protein
[SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]References
18573182,19047353,26651345,16306698,19940246,26367498,26400263,27558998 
