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rpoE [2017-8-11 16:0:3]
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rpoE [2017-8-11 16:0:3]

RNA polymerase delta subunit, affects the regulation of RNA polymerase by the concentration of the initiating nucleoside triphosphate (iNTP)
locus
BSU37160
pI
3.65
mw
20.25 kDa
protein length
173 aa Sequence Blast
gene length
519 bp Sequence Blast
function
transcription
product
RNA polymerase delta subunit
essential
no
ec
2.7.7.6
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.1|RNA polymerase]
  • Gene

    Coordinates
    3,812,542 → 3,813,063

    Phenotypes of a mutant

  • [protein|632C661255DD9C2865CB2F9D68A805997A833BCB|RpoE] is essential for cell survival when facing a competing strain in changing environment [Pubmed|23543716]
  • The protein

    Catalyzed reaction/ biological activity

  • binds to DNA immediately upstream of the promoter element at A-rich sequences on the abrB and rrnB1 promoters and facilitates open complex formation [Pubmed|26546673]
  • represses expression of ''[gene|29D91115BB3AC03538D618E54A5A57F92777EFF6|spo0B]'' [Pubmed|27679485]
  • Protein family

  • rpoE family (according to Swiss-Prot)
  • Structure

  • [PDB|2M4K] (full-length protein) [Pubmed|23868186]
  • [PDB|2KRC] (N-terminal domain) [Pubmed|20310067]
  • [SW|Localization]

  • closely associated with [SW|RNA polymerase] involved in transcribing both mRNA and rRNA operons [Pubmed|20724389]
  • Expression and Regulation

    Operons

    genes
    [gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE]-[gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG]
    description
    [Pubmed|29794222]

    regulation

  • the mRNA is processed between [gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE] and [gene|CEE04B9FED63AFEAB912791402F7578E852005D1|pyrG] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|YmcA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|YlbF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|YaaT] complex [Pubmed|29794222]
  • view in new tab

    genes
    [gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE]
    description
    [Pubmed|10336502]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17189250], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • view in new tab

    genes
    [gene|DEE0DA15EE9EA27BA8C332204E40D336324A111C|fadF]-[gene|7D89BBB52403BF99416250688EFA90C2BE8EB591|acdA]-[gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE]
    description
    [Pubmed|17189250]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17189250], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|FadR]: repression, [Pubmed|17189250], in [regulon|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|FadR regulon]
  • regulation

  • repressed in the absence of long-chain fatty acids ([protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|FadR]) [Pubmed|17189250]
  • view in new tab

    additional information

  • present at equimolar levels with [SW|RNA polymerase] [PubMed|20724389]
  • Labs working on this gene/protein

  • [SW|Arthur Aronson], Purdue University, West Lafayette, USA [http://wwwdev.gradschool.purdue.edu/PULSe/faculty.cfm?fid=5&range=0 homepage]
  • References

    Reviews

  • 22210308,25878038
  • Original publications

  • 7545758,7599136,7515111,10336502,2843435,17189250,3097010,6788769,23543716,22350953,20890634,20724389,20310067,23868186,21424579,24520113,24937760,24491578,26546673,27679485