rpoE [Mon Oct 10 2016 18:30:29 GMT+0200 (CEST)]

RNA polymerase delta subunit, affects the regulation of RNA polymerase by the concentration of the initiating nucleoside triphosphate (iNTP)

Locus: BSU37160

Isoelectric point: 3.00

Molecular weight: 20.00 kDa

Function: transcription

Product: RNA polymerase delta subunit

Essential: no

E.C.: 2.7.7.6

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → RNA synthesis and degradation → Transcription → RNA polymerase

Categories containing this gene/protein

• transcription

This gene is a member of the following regulons

• FadR regulon

Gene

Coordinates on the chromosome (coding sequence): 3,812,542 -> 3,813,063

Phenotypes of a mutant

• RpoE is essential for cell survival when facing a competing strain in changing environment PubMed

The protein

Catalyzed reaction/ biological activity

• binds to DNA immediately upstream of the promoter element at A-rich sequences on the abrB and rrnB1 promoters and facilitates open complex formation PubMed

Protein family

• rpoE family (according to Swiss-Prot)

Structure

• 2M4K (full-length protein) PubMed
• 2KRC (N-terminal domain) PubMed

Localization

• closely associated with RNA polymerase involved in transcribing both mRNA and rRNA operons PubMed

Interactions

• closely associated to RNA polymerase (RpoA(2)-RpoB-RpoC) PubMed
• associates only to the core RNA polymerase, not to the holoenzyme PubMed
• RpoB-RpoE (demonstrated for S. aureus) PubMed
• RpoC-RpoE (demonstrated for S. aureus) PubMed

Expression and Regulation

Operon

• fadF-acdA-rpoE PubMed
• rpoE PubMed

Sigma factor

• fadF: SigA PubMed
• rpoE: SigA PubMed

Regulation

• fadF: repressed in the absence of long-chain fatty acids (FadR) PubMed

Regulatory mechanism

• FadR: transcription repression PubMed

Additional information

• present at equimolar levels with [[RNA polymerase]] PubMed

Labs working on this gene/protein

• Arthur Aronson, Purdue University, West Lafayette, USA homepage

References

Reviews

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Original publications

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