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ahrC [Fri Dec 09 2016 16:43:56 GMT+0100 (CET)]
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ahrC [Fri Dec 09 2016 16:43:56 GMT+0100 (CET)]

transcriptional regulator of the ArgR family, AhrC represses the genes for arginine biosynthesis and activates the genes for arginine catabolism.
locus
BSU24250
pI
5.00
mw
16.00 kDa
function
transcriptional regulator of arginine metabolic genes
product
transcriptional regulator (ArgR family)
essential
no
synonyms
argR
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.4|Utilization of arginine/ ornithine]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|glutamate metabolism], [SW|utilization of amino acids], [SW|transcription factors and their control]

    • This gene is a member of the following [SW|regulons]

  • [SW|SR1 regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,522,324 -> 2,522,773

    The protein

    Catalyzed reaction/ biological activity

  • transcriptional activator/ repressor of genes involved in arginine metabolism

    • Protein family

  • [SW|ArgR family]

    • [SW|Cofactors]

  • L-arginine is the co-factor required for transcription repression/ activation

    • Structure

  • [PDB|2P5M] (C-Terminus), [PDB|2P5K] (complex with an 18bp DNA operator), [PDB|2P5L] (N-terminus), [PDB|1F9N], [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=18637 NCBI] [Pubmed|18455186],N-Terminus [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=60156 NCBI], C-Terminus [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=60157 NCBI], complex with an 18bp DNA operator [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=62912 NCBI]

    • [SW|Localization]

  • Cytoplasm

    • Expression and Regulation

    Operon

  • ''[protein|search|ahrC]-[protein|search|recN]'' [Pubmed|2106508]

    • Regulation

  • by [protein|search|sRNA] [protein|search|sr1]

    • Regulatory mechanism

  • inhibtion of translation upon binding of [protein|search|sr1] to the ''ahrC'' mRNA [Pubmed|17020585]

    • Additional information

  • expression is fourfold increased upon depletion of ''[SW|nusA]'' [http://www.nature.com/articles/nmicrobiol20157 Reference]

    • Biological materials

    Mutant

  • GP729 (aphA3), available in [SW|Stülke] lab

    • Labs working on this gene/protein

  • [SW|Simon Phillips], Leeds University, UK [http://www.astbury.leeds.ac.uk/People/staffpage.php?StaffID=SEVP Homepage]
  • [SW|Michel Debarbouille], Pasteur Institute, Paris, France [http://www.pasteur.fr/ip/easysite/go/03b-00000m-0ob/recherche/departements-scientifiques/microbiologie/unites-et-groupes/unite-de-biologie-des-bacteries-pathogenes-a-gram-positif/les-membres-de-l-equipe Homepage]

    • References

  • 17020585,17576690,18455186,18007040,18007039,11856827,11305941,9383188,7565595,1312212,2106508,27171430