stress-responsive membrane protease
function
quality control of membrane proteins
product
membrane protease
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.4|Additional proteins involved in proteolysis][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|membrane proteins], [SW|proteolysis]This gene is a member of the following [SW|regulons]
[SW|Rok regulon], [SW|YkrK regulon]Gene
Coordinates on the chromosome (coding sequence)
1,414,997 -> 1,415,893
Phenotypes of a mutant
increased sensitivity to membrane protein overproduction [Pubmed|22447908]increased sensitivity to dissipation of the membrane potential by the addition of valinomycin [Pubmed|22447908]The protein
Protein family
peptidase M48B family (according to Swiss-Prot)[SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|htpX]'' [Pubmed|22383849]Regulation
induced by membrane protein overproduction ([protein|search|YkrK]) [Pubmed|22624725,22447908]induced by dissipation of membrane potential (ΔΨ) by addition of a sublethal concentration of valinomycin [Pubmed|22447908]expression is increased due to mutations in ''[protein|search|resE]'', ''[protein|search|resB]'', ''[protein|search|sdhC]'', and'' [protein|search|sdhA]'' [Pubmed|22447908]induced by salt stress [Pubmed|22447908]Regulatory mechanism
[protein|search|YkrK]: transcription repression [Pubmed|22447908][protein|search|Rok]: transcription repression [Pubmed|22447908]Additional information
the mRNA is cleaved by [rnc|search|RNase III] [PubMed|26883633]References
22447908,22624725,22383849,23042994,26883633 
