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tagU [Mon Aug 31 2015 13:57:06 GMT+0200 (CEST)]
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tagU [Mon Aug 31 2015 13:57:06 GMT+0200 (CEST)]

phosphotransferase, attaches teichoic acid, teichuronic acid, or acidic capsular polysaccharide to cell wall peptidoglycan via phosphodiester linkage to N-acteylmuramic acid
locus
BSU35650
pI
9.53
mw
34.00 kDa
function
transfer of anionic cell wall polymers from lipid-linked precursors to peptidoglycan
product
phosphotransferase, responsible for attachment of anionic polymers to peptidoglycan
essential
no
synonyms
lytR
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.6|Export of anionic polymers and attachment to peptidoglycan]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
    • syns
    lytR

    [SW|Categories] containing this gene/protein

  • [SW|cell wall synthesis], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigM regulon], [SW|SigX regulon]

    • Gene

    Phenotypes of a mutant

  • a ''[protein|search|tagU]'' mutant has no phenoype, the triple ''[protein|search|tagT] [protein|search|tagU] [protein|search|tagV]'' mutant is unable to grow under normal conditions [Pubmed|21964069]

    • The protein

    Protein family

  • LytR-Cps2a-Psr family [Pubmed|19099556]

    • Paralogous protein(s)

  • [protein|search|TagT], [protein|search|TagV]

    • [SW|Cofactors]

  • Mg(2+) [Pubmed|21964069]

    • Structure

  • [PDB|3MEJ] ([protein|search|TagT], 36% identity, 69% similarity)

    • [SW|Localization]

  • cytoplasmic membrane (with extracytoplasmic catalaytic domain) [Pubmed|21964069]

    • [SW|Interactions]

  • [protein|search|MreB]-[protein|search|TagU] [Pubmed|21964069]

    • Expression and Regulation

    Operon

  • ''tagU'' [Pubmed|1357079]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1357079,9636707], [protein|search|SigM] [Pubmed|19047346], [protein|search|SigX] [Pubmed|1357079,9636707]

    • Regulatory mechanism

  • [protein|search|LytR]: autorepression [Pubmed|1357079]

    • References

    Reviews

  • 24024634

    • Original publications

  • 9636707,1357079,19099556,21964069