argC [Mon Aug 31 2015 13:53:36 GMT+0200 (CEST)]

N-acetyl-g-glutamyl-phosphate reductase

locus: BSU11190

pI: 5.00

mw: 37.00 kDa

function: biosynthesis of arginine

product: N-acetyl-g-glutamyl-phosphate reductase

essential: no

ec: 1.2.1.38

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|AhrC regulon], [SW|CodY regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,195,034 -> 1,196,071

The protein

Catalyzed reaction/ biological activity

• N-acetyl-L-glutamate 5-semialdehyde NADP phosphate = N-acetyl-5-glutamyl phosphate NADPH (according to Swiss-Prot)

Protein family

• Type 1 subfamily (according to Swiss-Prot)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|argC]-[protein|search|argJ]-[protein|search|argB]-[protein|search|argD]-[protein|search|carA]-[protein|search|carB]-[protein|search|argF]'' [Pubmed|7511775]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|7511775]

Regulation

• repressed by casamino acids ([protein|search|CodY]) [Pubmed|12107147]
• repressed by arginine ([protein|search|AhrC]) [Pubmed|1312212]

Regulatory mechanism

• [protein|search|AhrC]: transcription repression [Pubmed|1312212]
• [protein|search|CodY]: transcription repression [Pubmed|24843172]

References

• 6096675,2117746,7511775,12107147,24843172