two-component response regulator ([SW|OmpR family])
product
two-component response regulator ([SW|OmpR family])
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]Gene
Coordinates
278,377 279,057
The protein
Protein family
[SW|OmpR family] of two-component response regulatorsModification
phosphorylation by [protein|348F81B6ECB6FFBEC092A672FF5F40FE86918872|YcbM] ( on an aspartate residue, putative)Effectors of protein activity
activity is controlled by [protein|348F81B6ECB6FFBEC092A672FF5F40FE86918872|YcbM]-dependent phosphorylation (putative)Structure
[PDB|2OQR] (RegX3 from Mycobacterium tuberculosis, 38% identity) [pubmed|17942407][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|60DA46B02BB5F71337AF5F34921E2E68EC062EC7|ycbL]-[gene|348F81B6ECB6FFBEC092A672FF5F40FE86918872|ycbM]-[gene|FE7AC936BE959D745FBB6A88EAD64408C7177125|ycbN]-[gene|621FA6E2A76BB74F9051FBDB6857ED56F65BAB15|ycbO]
description
[pubmed|22383849]
view in new tabBiological materials
Mutant
MGNA-C034 (ycbL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2032 NBRP B. subtilis, Japan]BKE02550 ([gene|60DA46B02BB5F71337AF5F34921E2E68EC062EC7|ycbL]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE02550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATATGCGCTGCATCTCCT, downstream forward: _UP4_GGTTATAAATTAGGAGAGTTBKK02550 ([gene|60DA46B02BB5F71337AF5F34921E2E68EC062EC7|ycbL]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK02550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATATGCGCTGCATCTCCT, downstream forward: _UP4_GGTTATAAATTAGGAGAGTTReferences
10094672,23504016,17942407