comX [Thu Mar 03 2016 10:15:37 GMT+0100 (CET)]

competence pheromone precursor, transfers cell density signal to ComP; triggers the production of surfactin

locus: BSU31700

pI: 4.00

mw: 6.00 kDa

function: quorum sensing

product: competence pheromone precursor

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]

[SW|Categories] containing this gene/protein

• [SW|genetic competence], [SW|quorum sensing]

Gene

Coordinates on the chromosome (coding sequence): 3,255,853 -> 3,256,020

Phenotypes of a mutant

• the mutation suppresses the mucoid phenotype of ''[protein|search|motA]'' or ''[protein|search|motB]'' mutants due to loss of [protein|search|DegU] phosphorylation and concomitant reduced expression of the ''[protein|search|capB]-[protein|search|capC]-[protein|search|capA]-[protein|search|capE]'' operon [Pubmed|24296669]

The protein

Modification

• is synthesized as an inactive precursor, cleaved, and modified (prenylated) by [protein|search|ComQ] prior to excretion [Pubmed|22878193]

[SW|Localization]

• secreted (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|ComQ]-[protein|search|ComX] [Pubmed|22878193]
• [protein|search|ComP]-[protein|search|ComX]

Expression and Regulation

Operon

• ''[protein|search|comQ]-[protein|search|comX]'' [Pubmed|1715859]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|1715859]

References

Reviews

• 22024380

Original publications

• 16407988,11133937,12067344,19202088,14679219,15564679,17240141,19605685,1715859,22878193,24296669,22511326,21636272,24425772,24788106,25757097,26276536,26787913