fabI [2017-8-11 16:0:3]

enoyl-acyl carrier protein reductase

Locus: BSU11720

Isoelectric point: 5.61

Molecular weight: 27.72 kDa

Protein length: 258 aa

Gene length: 774 bp

Function: fatty acid biosynthesis

Product: enoyl-acyl carrier protein reductase

Essential: no

E.C.: 1.3.1.9

Synonyms: yjbW

Genomic Context

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Categories containing this gene/protein

• Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of fatty acids

Gene

Coordinates: 1,247,788 → 1,248,564

The protein

Catalyzed reaction/ biological activity

• Acyl-[acyl-carrier-protein] NAD = trans-2,3-dehydroacyl-[acyl-carrier-protein] NADH (according to Swiss-Prot)

Protein family

• FabI subfamily (according to Swiss-Prot)

Paralogous protein(s)

• FabL, one of the two proteins has to be present for viability PubMed

Effectors of protein activity

• inhibited by triclosan PubMed

Structure

• 3OIF (complex with NAD and inhibitor triclosan) PubMed

Additional information

• belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons

• Genes: fabI
  Description: PubMed

  Sigma factors

  • SigI: sigma factor, PubMed, in SigI regulon

  Regulatory mechanism

  • FapR: repression, PubMed, in FapR regulon

  Regulation

  • expressed when the cells experience a lack of malonyl-CoA (FapR) PubMed
  • expression of the operon is strongly reduced during biofilm formation PubMed

Biological materials

Mutant

• MGNA-B168 (yjbW::erm), available at the NBRP B. subtilis, Japan

References

Reviews

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Original Publications

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