fabI [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

enoyl-acyl carrier protein reductase

locus: BSU11720

pI: 5.00

mw: 27.00 kDa

function: fatty acid biosynthesis

product: enoyl-acyl carrier protein reductase

essential: no

ec: 1.3.1.9

synonyms: yjbW

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of lipids], [SW|most abundant proteins]

This gene is a member of the following [SW|regulons]

• [SW|FapR regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,247,788 -> 1,248,564

The protein

Catalyzed reaction/ biological activity

• Acyl-[acyl-carrier-protein] NAD = trans-2,3-dehydroacyl-[acyl-carrier-protein] NADH (according to Swiss-Prot)

Protein family

• FabI subfamily (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|FabL], one of the two proteins has to be present for viability [Pubmed|17114254]

Effectors of protein activity

• inhibited by triclosan [Pubmed|11325930]

Structure

• [PDB|3OIF] (complex with NAD and inhibitor triclosan) [Pubmed|21185310]

Expression and Regulation

Operon

• ''[protein|search|fabI]'' [Pubmed|12737802]

Regulation

• expressed when the cells experience a lack of malonyl-CoA ([protein|search|FapR]) [Pubmed|12737802]
• induced upon fatty acid biosynthesis inhibition [Pubmed|21383089]

Regulatory mechanism

• [protein|search|FapR]: transcription repression [Pubmed|12737802]

Additional information

• belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

References

Reviews

• 15952903,17919287

Original Publications

• 12737802,17114254,8953047,11007778,21185310,21383089,15378759