gerAB

nutrient receptor, germination response to L-alanine, triggers premature germination in response to morphological defects during sporulation

Locus: BSU_33060

Isoelectric point: 9.60

Molecular weight: 41.30 kDa

Protein length: 365 aa

Gene length: 1098 bp

Function: germination response to L-alanine

Product: nutrient receptor

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → Transporters/ other → Amino acid transporters → APC superfamily
• Lifestyles → Sporulation → Germination → Germinant receptors
• Groups of genes → Membrane proteins

Gene

Coordinates: 3,392,199 3,393,296

Phenotypes of a mutant

• suppresses the defects of spoVV mutant spores PubMed

The protein

Catalyzed reaction/ biological activity

• triggers premature germination in response to morphological defects during sporulation PubMed

Protein family

• amino acid-polyamine-organocation (APC) superfamily (according to UniProt)
• Spore germination protein (SGP) (TC 2.A.3.9) family (according to UniProt)

Paralogous protein(s)

• YndE, GerKB, GerBB

Localization

• predicted to be an integral membrane protein with ten membrane-spanning helices PubMed
• inner spore membrane PubMed

Expression and Regulation

Operons

• Genes: gerAA-gerAB-gerAC
  Description: PubMed

  Sigma factors

  • SigG: sigma factor, PubMed, in SigG regulon
  • SigF: sigma factor, PubMed, in SigF regulon

  Regulatory mechanism

  • SpoVT: repression, PubMed, in SpoVT regulon

  Regulation

  • expressed during sporulation in the forespore (SigF, SigG, SpoVT) PubMed

  Additional information

  • 1,100 molecules are present per spore PubMed

Biological materials

Mutant

• BKE33060 (gerAB::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_AACAATAGAAATACCTTGAA, downstream forward: _UP4_CTCAAGAGGAGGATTACAAC
• BKK33060 (gerAB::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_AACAATAGAAATACCTTGAA, downstream forward: _UP4_CTCAAGAGGAGGATTACAAC

References

Reviews

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Original publications

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